Nifelat - Use | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Nifelat is a medicine that contains nifedipine as active substance. It belongs to a group of medicines called calcium channel blockers. This medicine relax the blood vessels and threfore is used in the treatment of angina pectoris and high blood pressure (hypertension). Nifelat eases the flow of blood through the blood vessels (because of this effect, it is used to treat high blood pressure), and reduces the heart's need for oxygen (because of this effect, this medicine is used to treat angina pectoris).

Nifelat is one of the most commonly used medicine in the treatment of high blood pressure and angina pectoris. It can also be used to prevent migraine attacks.


Nifedipine cannot be used in the following conditions:

  • In patients who are allergic to nifedipine or other similar medicines such as:
    • nicardipine,
    • nimodipine,
    • verapamil,
    • diltiazem and others. If you experience symptoms of an allergy such as:
      • redness of the skin,
      • itching of the skin,
      • swelling of the face,
      • swelling of the tongue,
      • trouble breathing, contact your doctor immediately.
  • In patients with narrowing of the aorta (aortic stenosis), cardiogenic shock, heart failure, damage to the aortic valve and in patients who have had a heart attack. These patients should not use Nifelat tablets.
  • If you are planning an operation, tell your doctor that you are using this tablets.
  • In patients with liver disorder.
  • Patients with kidney disorder.
  • Diabetes.

Caution is needed in elderly patients, due to its stronger and more potent effect in elderly patients.

Nifelat cannot be used in combination with alcoholic beverages, grapefruit and St. John's wort.

Use during pregnancy and breast-feeding

It can be used during pregnancy only if the benefit to the mother outweighs the risk to the child.

Nifelat passes into breast milk. Avoid breastfeeding your baby while using Nifelat.

How to use

Usual initial dose is 10 mg, three times daily in the treatment of hypertension (high blood pressure), in the treatment of angina and to prevent migraine attacks. The dose can be increased gradually, as needed (not more than 120 mg a day).

Dosage form also include sustained release tablet. Sustained release tablet should be taken only once a day (30-60 mg).

Nifelat can be taken with food or on an empty stomach. Sustained release tablets should be taken on an empty stomach, because food may decrease efficacy of Nifelat.

The maximum daily dose of Nifelat is 120 mg.

At the beginning of treatment you will need to have more often blood pressure check, because that is how your doctor will determine which dose is appropriate for you.

At the beginning of treatment, Nifelat may lead to worsened symptoms of angina. Tell your doctor if you experience worsened symptoms of angina.

You will need to take this drug, as long as your doctor recommended, regardless of whether you feel good or not. High blood pressure, often do not cause any symptoms, and you can feel good, but that does not mean you do not have to this medicament. High blood pressure can cause heart attack or stroke, therefore you will need check your blood pressure more often.

Nifelat should not be used with grapefruit juice, because grapefruit can increase the efficacy of Nifelat.


If you take more Nifelat tablets, than your doctor recommended, hypotension (low blood pressure) and slow heart beat (bradycardia) may occur. If you experience symptoms such as:

  1. dizziness,
  2. fainting,

contact your doctor immediately. Dizziness can be severe when getting up too quickly from a seated or lying position. If dizziness occurs, the patient should be placed on a bed and raise his arms and legs.

Use with other medicines (Interactions)

Nifelat cannot be used or can be used only with great caution with the following medications:

  • Medicines used for HIV treatment, such as:
    • ritonavir,
    • saquinavir,
    • efavirenz.
  • Drugs used in the treatment of diabetes mellitus such as:
    • metformin (Gluformin),
    • glibenclamide,
    • glipizide,
    • glimepiride and others, because Nifelat, may change efficacy of these medicines.
  • Medicines used for epilepsy treatment, such as:
    • carbamazepine,
    • phenytoin,
    • phenobarbital.
  • Medicines used in the treatment of bacterial and fungal infections, such as:
    • erythromycin,
    • clarithromycin,
    • telithromycin,
    • rifampicin,
    • isoniazid,
    • ketoconazole,
    • itraconazole.

It cannot be used in combination with alcoholic beverages, because it can lead to the side effects.

Side effects

Nifelat may cause the following side effects:

  1. nausea,
  2. vomiting,
  3. constipation,
  4. headache,
  5. dizziness,
  6. flushing,
  7. dizziness,
  8. mood changes,
  9. rapid heartbeat (tachycardia),
  10. swelling of the joints,
  11. chest pain,
  12. tremor,
  13. flu-like symptoms (cough, sore throat, fever),
  14. heartburn,
  15. allergy and others.

Tell your doctor if you experience any side effect.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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