Nifuroxazide

Nifuroxazide - Use | Side Effects | Dosage

Nifuroxazide belongs to the group of the intestinal anti-infective drugs. It is available as an over the counter medication for the treatment of acute diarrhea if it is caused by bacteria. Studies have shown that this medication reduces the number of stools after only two days of treatment and reduces the duration of diarrhea for around twenty four hours. Nifuroxazide does not affect the intestinal flora.1

Precautions

Contraindication to the use of the Nifuroxazide is hypersensitivity to this substance.

Nifuroxazide should not be taken in the following situations:

  • If you have bloody stools
  • If you have a fever
  • If you are vomiting

If diarrhea persist after three days of treatment, you should contact your doctor.

Nifuroxazide can cause acute pancreatitis2, so if you notice symptoms, such as: nausea, vomiting and abdominal pain, immediately discontinue use and contact your doctor.

Nifuroxazide does not improve dehydration so you must follow certain dietary regimen in order to avoid dehydration and loss of minerals and vitamins. It is recommended to eat rice, bananas, grilled meat and mint tea while you're having diarrhea, because these foods are proven to be useful in relieving diarrhea. Avoid milk, dairy products and chamomile tea.

Nifuroxazide capsules should not be used in children younger than 6 years, because capsules are too big to swallow and may cause choking. In these children it is recommended to use Nifuroxazide oral suspension 200 mg / 5 ml.

Nifuroxazide, pregnancy and breastfeeding

In animal studies Nifuroxazide did not show any teratogenic effects, and teratogenicity is not expected in humans as well. However, there are no studies on humans, and because of that use of this drug during pregnancy should be avoided. In pregnant women, diarrhea should be treated primarily by making changes in the diet.

You may breastfeed your baby, but only if you're Nifuroxazide for short-term treatment (no longer than three days).

Dosage

The usual dose for children aged 6-18 years is 200 mg three times a day. In adult patients, the recommended dose is 200 mg four times a day. Duration of therapy should not be longer than seven days.

In children aged 2-6 years Nifuroxazide should be taken as oral suspension 200 mg / 5 ml. Recommended dose is 5 ml three times a day. Use of this drug in children younger than 2 years is not recommended.

This drug can be taken regardless of meals.

Interactions

Nifuroxazide should not be administered concomitantly with following drugs:

  • Metronidazole (a drug used in the treatment of anaerobic infections and infections caused by parasites)
  • Sulfonamides (e.g. Bactrim), which is mainly used to treat urinary tract infections
  • Cephalosporins (antibiotics)
  • Chloramphenicol (also an antibiotic mostly used in the form of ointments and creams)
  • Nitrofurantoin (a drug used to treat urinary tract infections)
  • Griseofulvin - a drug used in the treatment of fungal infections

Nifuroxazide should never be administered in combination with the above mentioned drugs as this increases the risk of disulfiram-like reaction, which is characterized by: severe nausea and vomiting, headache and rapid heartbeat.

Also, this drug should not be administered simultaneously with sedatives (e.g. benzodiazepines, such as: bromazepam, alprazolam, lorazepam, midazolam and others).

Side effects

Nifuroxazide may cause the following side effects:

  • Quincke's edema (angioneurotic edema which includes subcutaneous tissue and is characterized by allergic reaction)
  • Urticaria
  • Anaphylactic shock

References

  1. NCBI link 1
  2. NCBI link 2