Pantoprazole - Use | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Pantoprazole belongs to the group of medicines called proton pump inhibitors (PPI). Pantoprazole blocks the proton pump in gastric parietal cells, and thereby reduces the secretion of gastric acid. Because of this effect, pantoprazole is used in the treatment of the following conditions:

  • Treatment and prevention of ulcers in the stomach or duodenum
  • Treatment of gastroesophageal reflux disease (GERD)
  • Treatment of Zollinger-Ellison syndrome

Beside taking Pantoprazole, you will also need to change your diet and lifestyle:

  • Avoid fatty and spicy foods
  • Stop smoking
  • Avoid alcoholic beverages
  • Avoid stress
  • Make sure you have more smaller meals during the day
  • When you sleep, tilt the head of your bed upward to raise your head
  • Eat a lot of milk products


Pantoprazole cannot be used if you are allergic to pantoprazole or other similar medicines, such as: omeprazole, esomeprazole and others. Symptoms of an allergic reaction are the following: itching, redness, swelling of the face, swelling of the tongue, difficulty breathing. If you experience any symptoms of allergy, contact your doctor immediately.

Pantoprazole can be used cautiously in patients with liver damage as well as in patients using non-steroidal anti-inflammatory medicines, such as: ibuprofen (Brufen), diclofenac (Diklofen), indomethacin, meloxicam (Movalis), celecoxib, rofecoxib and others.

It is very important to exclude digestive cancer as a possible diagnosis before you start using Pantoprazole, because Pantoprazole may mask the cancer symptoms. If you experience following symptoms, you should contact your doctor immediately: painful swallowing, blood in the stool (dark stool), vomiting which may be accompanied with blood and weakness.

Pantoprazole rarely may lead to vitamin B12 deficiency and anemia. Tell your doctor if you have or have ever had anemia.

Pantoprazole may reduce the level of magnesium in the blood and lead to hypomagnesaemia. Consult your doctor if you experience numbness or heart disorders (such as rapid heart beat), because these symptoms occur in hypomagnesaemia.

If used for a long time Pantoprazole may lead to bone damage and therefore increases the risk of bone fractures. Tell your doctor if you have had any bone disease (e.g, osteoporosis).

Use od Pantoprazole during pregnancy and breastfeeding

Pantoprazole should be used during pregnancy only if the benefit to the mother outweighs the risk to the child.

Pantoprazole can pass into breast milk. Avoid breastfeeding while using Pantoprazole.

How to use

Pantoprazole should be used in the morning, after getting up, with a 8 fluid ounce glass of lukewarm water. Do not crush the tablet but swallow it whole. After you take a pill, you should not eat breakfast the next half hour.

The usual dose of the Pantoprazole in patients older than 12 years is 20 mg once a day (take the tablet first thing in the morning). Dose may be increased in severe conditions.

Pantoprazole starts working after a few days, so you cannot expect improvement of symptoms in the first days of using Pantoprazole.

How long you will use Pantoprazole depends primarily on the severity of the condition. Your doctor will tell you how long you need to use Pantoprazole.

Use with other medicines (Interactions)

Pantoprazole cannot be used in combination with the following medicines:

  • Anticoagulants, used in the treatment of thrombosis, such as: warfarin (Farin), acenocoumarol (Sintrom, Sinkum 4).
  • Digoxin, used in the therapy of heart failure
  • Medicines used in the treatment of fungal infections, such as: itraconazole, fluconazole, ketoconazole.
  • Antibiotics such as: ampicillin, amoxicillin, rifampicin.
  • Medicines used in the treatment of AIDS (HIV)
  • Methotrexate, used to treat breast cancer
  • St. John's Wort

Tell your doctor about all medications and herbal (OTC) medicines you are taking.

Side effects

Pantoprazole may cause the following side effects: nausea, vomiting, diarrhea (which may be accompanied by blood), bloating, abdominal pain, dry mouth, flu-like symptoms (sore throat, fever), hallucinations, muscle pain, headache, flushing, dizziness, liver damage (which is manifested by the appearance of jaundice-yellowing of the skin and eyes), anemia, allergy and others.

If you experience any side effects you should contact your doctor.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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