Protonix - Use | Dose | Side Effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Protonix (Pantoprazole) blocks the 'pump' that produces stomach acid. Thus reducing the amount of stomach acid in your stomach. Protonix is used as a short-term therapy for reflux symptoms (heartburn, acid regurgitation) in adults. Reflux is acid reflux from the stomach into the esophagus, which can lead to inflammation and pain of the esophagus. This can lead to symptoms such as painful burning sensation in the chest rising up to the throat (heartburn) and a sour flavor in the mouth (acid regurgitation). Symptoms relief of acid reflux and heartburn can feel after just one day of treatment with Protonix, but this medicine is not intended to lead to the immediate relief of symptoms. It may be necessary to take the medicine for 2-3 days in a row to get symptoms relief.

Do not use this medicine

  • If you are allergic (hypersensitive) to Protonix or any other ingredients.
  • If you are taking medicine containing atazanavir (for the treatment of HIV infection).
  • If you are under 18 years of age.
  • If you are pregnant or breast-feeding.

Be careful when applying this medicine

First, consult your doctor or pharmacist if:

  • You have been 4 weeks or more continuously treated for heartburn or indigestion.
  • You are older than 55 years, and every day you are taking medications that are available without a prescription for the poor digestion treatment.
  • You are over 55 years old and you have new or recently changed symptoms.
  • You have had a stomach ulcer or have undergone surgery in the stomach.
  • You have a problem with your liver or jaundice (yellowing of the skin or eyes).
  • Regularly visiting the doctor for a serious problem or condition of the body.
  • Should be subjected to endoscopy or urea breath test or C-urea test.

Inform your doctor immediately, before or after taking this medicine, if you notice any of the following symptoms, which could be a sign of other, more serious diseases:

  • Unplanned weight loss (which is not related to diet or exercise program)
  • Vomiting, especially if repeated
  • Blood Vomiting, which can appear as dark coffee grounds in the vomit
  • Notice blood in stool, which can be color or black tar
  • Difficulty swallowing or pain when swallowing
  • You look pale and feel weak (anemia)
  • Pain in the chest
  • Pain in the stomach
  • Severe and / or persistent diarrhea, because Protonix is associated with a small increase in the frequency infectious diarrhea.

Your doctor may decide that you need to do some testing. If you need to do a laboratory blood test, tell your doctor if you are taking medication Protonix. Relief of symptoms of acid reflux and heartburn can feel after just one day of treatment with Protonix, but this medicine is not intended to lead to the immediate relief of symptoms. You should not use it as a preventive measure. Do not forget to visit your doctor regularly if you suffer from the symptoms of heartburn and indigestion, which are repeated for some time.

Interactions (The usage of other medicines)

Protonix can prevent proper functioning of certain medicines. Tell your doctor or pharmacist if you are taking medicines containing any of the following active ingredients:

  • Ketoconazole (used for fungal infections)
  • Warfarin and phenprocoumon (used to thin the blood and prevent the formation of blood clots). You may need to do additional laboratory blood tests.
  • Atazanavir (used in HIV infection). You can not take Protonix if you are already taking atazanavir.

Do not take Protonix simultaneously with other medicines that reduce the amount of acid in the stomach, like other proton pump inhibitors (omeprazole, lansoprazole or rabeprazole) or H2 antagonist (eg ranitidine, famotidine). However, Protonix can be taken with antacids (eg magaldrat, alginic acid, sodium bicarbonate, aluminum hydroxide, magnesium carbonate or combinations thereof), if necessary.

Taking Protonix with food and liquid

Medicine should be swallowed whole with water and before meals.

Medicines use during pregnancy and breastfeeding

Do not take Protonix if you are pregnant, think you are pregnant, or are breast-feeding. Before taking any medication consult your doctor or pharmacist.

The effect of this medicine on the management of motor vehicles and machinery operation

You should not drive a car or operate machinery if you have side effects such as dizziness or visual disturbances.

Medicines use

Take medicine Protonix always, exactly as described in by your doctor. If you are not quite sure, check with your doctor or pharmacist. Take one tablet a day. Do not exceed the recommended dose of 20 mg Protonix per day. This medicine should not take 2-3 days in a row. Stop taking the medicine when you no longer have symptoms. Relief of symptoms of acid reflux and heartburn can feel after just one day treatment with Protonix, although the medicine is not intended to lead to the immediate relief of symptoms. Tell your doctor if you feel the relief of symptoms after 2 weeks of continuous intake of this medicine. Do not take this medicine for more than 4 weeks without consulting a doctor. Take a pill before a meal, every day at the same time. You should swallow the tablet whole with some water. Do not chew or crush the medicine.


Inform your doctor or pharmacist if you take higher dose than you should. If possible take your medicine with you. Overdose symptoms are not known!

If you forget to take the medicine

Do not take a double dose to make up the missed dose. Take your next, normal dose the next day at the usual time. If you have any questions about using this medicine, ask your doctor or pharmacist.

Side effects

Tell your doctor immediately or contact your nearest emergency department if you notice any of the below mentioned serious side effects. Immediately stop taking the medicine

Severe allergic reactions (rare)

Hypersensitivity reactions, called anaphylactic reactions, naphylaxis or angioedema. Typical symptoms are: swelling of the face, lips, mouth, tongue and / or throat, which may cause difficulty in swallowing or breathing, hives (itching after contact nettle), severe dizziness accompanied by a racing heart and heavy sweating.

Serious skin changes (frequency unknown)

Rash with swelling, blisters and peeling skin loss of skin and bleeding around the eyes, nose, mouth or genitals and rapid deterioration of general condition, or rash when exposure to the sun.

Other serious side effects (frequency unknown)

Yellowing of the skin and eyes (due to severe liver) or renal impairment accompanied by pain during urination, pain in the lower back followed fever.

Uncommon side effects

Headache dizziness; diarrhea; nausea, vomiting and bloating gases; prison, dry mouth; abdominal pain and discomfort; rash or hives; itching; feeling of weakness, exhaustion and general poor condition; sleep disorders; increased liver enzymes in the blood laboratory tests.

Rare side effects

disruption or complete loss of taste; visual disturbances such as blurred vision; joint pain; pain muscle, changes in body weight; elevated body temperature, swelling of the limbs; allergic reactions, depression; higher levels of bilirubin in the blood and fat (based on laboratory tests of blood), increase in breast males temperatures and a significant decrease in the number of granular white blood cells in the circulation.

Very rare side effects

disorientation; decreased number of blood platelets, which can cause bleeding or bruising more often than usual; reduced number of white blood cells, which can lead to frequent infections; simultaneously unusual decrease in the number of red and white blood cells, and platelets (based on blood tests).

Unknown frequency

hallucinations, confusion (especially in patients with a medical history of these symptoms); reduced concentration of sodium in the blood, reduced concentration of magnesium in the blood. If any of the side effects gets serious, or if you notice any side effects not listed here, please tell your doctor or pharmacist! This medicine is also known as: Somac, Tecta, Pantoloc, Controloc, Pansiv, Protium, Pantoprazole, Pantecta, Pantoheal, Pantpas, Ppi-40, Neoppi

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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