Quinapril - Dose | Side effects | Use

Quinapril is the drug from the group of ACE inhibitors (ACE - angiotensin converting enzyme). By blocking this enzyme it leads to dilation of blood vessels, easing the blood flow through the blood vessels, therefore reduces blood pressure.

It is used to treat heart failure and hypertension (high blood pressure). This drug can be used alone or in combination with diuretics (water pills), except with potassium-sparing diuretics (spironolactone, triamterene, amiloride, eplerenone).


It should be avoided in the following conditions:

  • If you have or have had angioedema, caused by ACE inhibitors.
  • You are allergic to Quinapril or other similar drugs:
    • enalapril,
    • ramipril,
    • captopril,
    • quinapril,
    • perindopril,
    • lisinopril and others.
  • Abnormal narrowing of the aorta (aortic stenosis).
  • Pregnant or breastfeeding.
  • If you have systemic lupus erythematosus
  • Rheumatoid arthritis.
  • Hypotension (low blood pressure).
  • If you have high levels of potassium in the blood (hyperkalemia).

It should be used with caution in patients with kidney disorders.

Quinapril should be avoided in combination with the alcoholic beverages, because the alcohol may hamper the efficacy.

At the beginning of therapy, you may have hypotension (low blood pressure), especially when you are getting up suddenly from a lying position. If dizziness occur, it may be a sign that hypotension has occured. Such a patient should be placed in the supine position and raise his hands and feet. Tell your doctor if you are experiencing dizziness or you feel like you are going to lose consciousness.

You will also need to change your lifestyle habits in order to successfully maintain blood pressure within normal limits:

  • Avoid stress.
  • Quit smoking.
  • Exercise at least half an hour a day.
  • Eat fish at least 3 times a week and increase an intake of fruits and vegetables.
  • Avoid fatty and spicy foods.

Use during pregnancy and breastfeeding

According to the US Agency for Food and Drug Administration, Quinapril belongs to the group D (FDA: Group D). This means that studies have shown that it is harmful to fetus and should not be used during pregnancy!

Quinapril passes into breast milk, therefore you should avoid breastfeeding while using this drug. Instead of breastfeeding your baby, you can give your baby formula milk.

Quinapril dose and use

  • It should be used once a day, every day at the same time.
  • The initial dose for the treatment of high blood pressure is 10 mg per day. Dosage can be increased until the desired effect is achieved. The usual maintenance dose is in the range of Quinapril 20 mg to 40 mg once a day or divided into two doses (10 mg or 20 mg twice a day).
  • This medicament should be used in lower doses for the treatment of heart failure (2.5 mg daily). Dosage may be increased as needed.
  • You should use this drug for as long as recommended by your doctor. Since high blood pressure usually causes no symptoms, you may feel good, but no matter, you will still need to take your medicine.
  • Avoid standing up too quickly while using Quinapril, because you may develop orthostatic hypotension (feeling dizzy or lightheaded due to a sudden drop in blood pressure because of standing up too quickly from sitting or lying position).
  • It should not be used in combination with alcohol!

Use with other medicines (Interactions)

Quinapril should be avoided in combination with the following medicines:

  • Medicines used for the treatment of pain, rheumatism and fever, such as:
    • Diclofenac (Diklofen),
    • Ibuprofen (Nurofen),
    • Ketoprofen,
    • Furbiprofen,
    • Sulindac,
    • Indomethacin and others. These drugs as well as Quinapril, can increase potassium levels in the blood. Increased levels of potassium in the blood can cause dangerous arrhythmias (irregular heartbeat)! Therefore, the combination with these medications is not recommended!
  • Potassium supplements (e.g. KCl - potassium chloride). Concomitant use with these medicines may increase potassium levels in the blood and cause arrhythmias (irregular heartbeat).
  • Potassium-sparing diuretics (water pills), such as:
    • spironolactone,
    • eplerenone,
    • triamterene,
    • amiloride. Concomitant use with these medications can increase potassium levels in the blood and lead to cardiac arrhythmias (irregular heartbeat).
  • Tetracycline, medicine used to treat infections. Quinapril may reduce the effect of these drugs.
  • Immunosuppressive drugs used to treat autoimmune diseases, such as:
    • cyclophosphamide,
    • azathioprine,
    • cyclosporin and others.
  • Allopurinol, used for the treatment of gout.
  • Corticosteroids, medications used for the treatment of inflammatory conditions, such as:
    • methyl prednisolone,
    • prednisolone.
  • Medicines used for treatment of diabetes, such as:
    • insulin,
    • aliskiren. Quinapril may enhance the effect of these drugs and cause hypoglycemia (low blood glucose).
  • Lithium, used for the treatment of depression.
  • Antacids, used for the neutralization of the gastric acid, such as:
    • aluminum hydroxide,
    • magnesium hydroxide,
    • sodium hydrogen carbonate, and others. These drugs can reduce the effect of Quinapril.

Tell your doctor about all medications and herbal products you are using.

Quinapril side effects

Quinapril may cause high potassium levels (hyperkalemia), which is manifested by the appearance of muscle weakness and irregular heartbeat. If you are experiencing these symptoms, contact your doctor immediately.

Dry and persistent cough may occur very often. Sometimes the cough is so persistent that your doctor will need to prescribe other medicine.

Quinapril may cause the following side effects:

  1. headache,
  2. dizziness,
  3. fainting,
  4. hypotension (low blood pressure),
  5. decreased urination,
  6. nausea,
  7. vomiting,
  8. flu-like symptoms (cough, fever, sore throat),
  9. reducing the number of leukocytes in the blood (leukopenia),
  10. liver damage that is manifested by the appearance of dark urine and jaundice (yellowing of the skin and eyes),
  11. dry mouth,
  12. abdominal pain,
  13. allergy and others.

Tell your doctor if you are experiencing any side effects.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.