Raciper

Raciper - Use | Dosage | Side Effects

Raciper belongs to family of medications called proton pump inhibitors (PPIs). Raciper blocks enzyme called H,K ATPase (enzyme that pumps gastric acid), thus inhibiting gastric acid secretion.1 If you are interested in detailed mechanism of action, you should read this article

Because of such effects, this drug is used to treat:

  • Zollinger-Ellison syndrome
  • Gastroesophageal reflux disease (GERD)
  • Duodenal ulcer disease
  • Gastric ulcer disease
  • Heartburn

Beside using Raciper, you'll need to make some lifestyle changes if you want to improve ulcer healing. Try to avoid eating large meals, spicy food (such as chili peppers) and high-fat foods. Also, the consumption of alcohol is strictly forbidden. Try to eat 5-7 small sized meals during the day. Milk and diary products are also recommended.

Precautions

Raciper should be avoided if you have ever had allergic reaction to the Raciper or other proton pump inhibitors.

Raciper should be used with extreme precautions in patients with following conditions:

  • Hepatic function impairment
  • Renal function impairment
  • Hypomagnesemia (condition in which blood magnesium levels are lower than normal)
  • Osteoporosis (condition in which bones are weaker and more prone to fractures). Studies have shown that long-term use of this drug is associated with increased risk of bone fractures.2

Raciper safety in pregnang woman and breastfeeding mothers

There are no reliable data regarding Raciper safety during pregnancy. It is mostly recommended to make lifestyle modifications in order to relieve symptoms of heartburn, GERB or ulcers.

There are no studies about Raciper use in breastfeeding mothers. For these reasons, breastfeeding should be avoided while on Raciper therapy.

Recommended dosage

It is important to remember that Raciper is most effective if taken on an empty stomach (especially if taken in the morning).

Long-term use of Raciper may cause bone fractures, vitamin B12 deficiency and mineral deficiencies. Raciper should not be used in patients under the age of 12.

Initial dose of Raciper is 20 mg once a day (on an empty stomach). In severe conditions, dose of Raciper may be increased to 40 mg in divided doses (20 mg in the morning and 20 mg before you go to bed).

Raciper and its interactions

Raciper should be avoided simultaneously with the following medications:

  • Medications for heart failure (e.g. digoxin)
  • Medications for thrombosis (e.g. warfarin)
  • Anitretroviral medicines, such as:
    • nelfinavir,
    • saquinavir,
    • efavirenz, and others.
  • Medications for fungal infections treatment, such as:
    • ketoconazole,
    • itraconazole, and others.
  • Medications for bacterial infections, such as:
    • ampicillin,
    • amoxicillin,
    • rifampicin, and others.
  • Medications that have impact on bowel movements (e.g. cisapride)
  • Seizure medications
  • Benzodiazepines (e.g. bromazepam and lorazepam)
  • Medications used in the treatment of depression (e.g. citalopram, escitalopram, imipramine, desipramine, amitriptyline)
  • St. John's Wort.
  • Immunosuppressives (e.g. tacrolimus)
  • Inhibitors of platelet aggregation (e.g. clopidogrel)

Tell your doctor about all medicines and herbal remedies you are taking.

Side effects

Raciper may cause following adverse effects:

  1. nausea,
  2. vomiting,
  3. belching,
  4. abdominal cramps,
  5. diarrhea
  6. headache,
  7. facial flushing,
  8. dry mouth,
  9. dizziness,
  10. mood swings,
  11. hallucinations,
  12. alopecia (hair loss),
  13. Impaired taste
  14. renal function impairment (symptoms of renal function impairment inculde: difficult urinating and blood in the urine)
  15. hepatic damage
  16. gynecomastia (breast enlargement),
  17. Low white blood cell count
  18. allergic reaction

Tell your doctor if you are experiencing any adverse effects.

References

  1. Jai MS, George S. Pharmacology of Proton Pump Inhibitors. Curr Gastroenterol. Rep. 2008: 10 (6): 528-534.
  2. Tetsuhide I, Robert TJ. Association of Long-term Proton Pump Inhibitor Therapy with Bone Fractures and effects on Absorption of Calcium, Vitamin B12, Iron, and Magnesium. Curr Gastroenterol. Rep. 2010: 12 (6): 448-57.