Ranzepam - Dosage | Pregnancy | Use
Ranzepam is a drug that belongs to the group of benzodiazepines. Its active ingredient is diazepam. It is used to treat the following conditions:
- Muscle spasticity
- Preoperative sedation
Ranzepam is contraindicated in the following conditions:
- Myasthenia gravis
- Severe hepatic impairment
- Chronic obstructive pulmonary disease or other breathing problems. There have been reports of respiratory depression in patients taking this medicine.
- If you have or have had sleep apnea syndrome. There have been reports of sleep apnea syndrome in patients who have been treated with benzodiazepines.
- Chronic psychosis
- Obsessive disorders
Ranzepam should be applied very cautiously in the following conditions:
- Moderate damage to the liver or kidneys
- Alcoholism. Concomitant use with alcoholic beverages increases the risk of moving from a state of mild or moderate sedation into a deeper level of unconsciousness and even coma!
Ranzepam, pregnancy and breastfeeding
Lisa D. et al in the meta-analysis published in BMJ have reviewed about 1400 published clinical studies regarding Ranzepam use during pregnancy (all studies since 1966 were included). It was concluded that the results of cohort studies do not suggest that Ranzepam increases the risk of major malformations or cleft palate in newborns, while the results of case-control studies suggest that Ranzepam significantly increases the risk of major malformations and cleft palate. For this reason, this drug should be used during pregnancy only if necessary. Pregnant women who're using this drug during pregnancy need to be regularly monitored (ultrasound) to determine on time if some malformation has occurred.
Avoid breastfeeding while taking this medication.
Recommended dosage is given in the table below:
|Anxiety||Maximum daily dose is 30 mg, divided into 2-6 doses. Duration of treatment: not more than three months|
|Insomnia||5-15 mg taken as a single dose, half an hour before bedtime. Duration of treatment: not more than one month|
|Muscle spasticity||5 mg three times a day. Duration of treatment: not more than two weeks|
|Cerebral spasticity||Maximum daily dose is 60 mg divided into 4-6 doses.|
|Preoperative sedation||5-20 mg half an hour or an hour prior surgery|
In the elderly patients, lowest effective dose should be used. This drug causes drowsiness, and increases risk of falls and bone fractures in the elderly.
Abrupt discontinuation of therapy
Abrupt discontinuation of Ranzepam treatment may produce the following symptoms:
- Worsening of anxiety or insomnia
- Muscle pain
- Abnormal behavior
Effect on ability to operate machinery
This drug exerts a strong sedative activity, which can also be reflected in the form of excessive sleepiness during the day and during the performance of various activities. Therefore, operating machinery should be avoided while using this drug.
Symptoms of an overdose include loss of coordination of movements, jerky eye movements, excessive drowsiness and slurred speech.
Ranzepam should not be administered concurrently with the following drugs:
- Selective serotonin reuptake inhibitors (sertraline, fluoxetine, paroxetine, fluvoxamine, etc.)
- Serotonin and noradrenaline reuptake inhibitors (venlafaxine and doxepin)
- Narcotic analgesics (codeine, oxycodone, alfentanil, dezocine, hydrocodone, fentanyl, dihydrocodeine, morphine, and tramadol)
- Butyrophenone antipsychotics (haloperidol and droperidol)
- H1 antihistamines with sedative effects (dimenhydrinate and loratadine)
Adverse effects reported during Ranzepam use are following:
- Respiratory depression (difficulty breathing)
- Sudden, strong urge to urinate
- Hallucinations and delusions
- Aggression and anger
- Behavior changes
- Loss of coordination
- Retrograde amnesia
- Slowed reaction time
- Slurred speech
- Dry mouth
- Hepatic impairment
- Increased libido
- Decreased libido
- Double vision
Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.
If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.