Staphylex - Usage | Precautions | How to use
Staphylex is a drug that contains flucloxacillin as an active substance. It belongs to the group of antibiotic drugs and class of penicillin antimicrobial agents. Its bactericidal effect results from the binding of this drug to penicillin binding protein (PBP) and consequent inhibition of bacterial cell wall synthesis. It is resistant to the action of enzymes that decompose penicillin antibiotics (so-called penicillinase), but also to cephalosporinase (an enzyme that decompose cephalosporins). Staphylex is also resistant to the action of extended-spectrum beta-lactamase, which is why it exhibits a strong bactericidal effect on both gram-positive and gram-negative aerobic and anaerobic bacteria.
Because of the abovementioned effects, Staphylex is used to treat the following infections:
- Ear infections (otitis externa and otitis media).
- Lung infections (e.g. pneumonia and lung abscess).
- Sinusitis (infection of the sinuses).
- Infections of the throat and tonsils (tonsillitis and peritonsillary abscess).
- Nose infections.
- Urinary tract infections.
- Heart infections (e.g. endocarditis).
- Brain infections (meningitis).
- Blood infections (septicemia).
- Infected wounds or various skin abscesses.
- Skin eczema.
- Digestive tract infections (e.g. enteritis).
It is also used for prophylactic purposes before major surgeries. It is effective only if infection is caused by susceptible microorganism.
Staphylex should not be used in patients with kidney problems due to an increased risk of convulsions (especially if taken in high doses).
Its use is absolutely contraindicated in patients who are allergic to penicillin or to the active substance flucloxacillin. There is a risk of developing allergy in patients with known allergy to cephalosporins or imipenem and aztreonam. If you are not sure that you are allergic to any of these medicines, contact your doctor.
Patients who have liver problems should not take this medicine because there is a risk of deterioration in liver function. If you notice pain in the upper right abdomen or jaundice, contact your doctor immediately.
According to PIL, this medicine should not be used in patients older than 50 years nor in patients who have severe illness.
This medicine can only be taken with a doctor's prescription and only in the manner prescribed by your doctor.
Staphylex, Pregnancy and Breastfeeding
There is insufficient data on the use of this medication during the pregnancy and lactation, and for this reason its use is not recommended. Consult your doctor if you are pregnant or think you are pregnant.
Staphylex passes into breast milk and therefore breastfeeding should be avoided while taking Staphylex.
How to use
For severe heart or bone infections in adult patients: up to 8 g per day divided into 3 or 4 doses.
The usual dose for the treatment of most infections is 250 mg four times a day, but the dose depends on the severity of the infection and individual health. Your doctor will determine the dose that is best for you.
Usual dosage in children (according to PIL):
|10-18 years||250 mg, four times a day|
|2-10 years||125 mg, four times a day|
|Children younger than 2 years||62.5 mg, four times a day|
The pediatrician will determine the dose that is best for your child.
It is recommended that you take Staphylex capsules on an empty stomach (2 hours before or 2 hours after meals).
Staphylex should not be used concomitantly with the following medicines:
- Oral contraceptive pills - it is known that most antibiotics, including flucloxacillin, reduce the effect of oral contraceptive pills. Use alternative methods of contraception while using Staphylex.
- Warfarin - an anticoagulant drug. Staphylex can reduce the anticoagulant effect of warfarin.
- Probenecid - a medicine used to treat gout. Probenecid increases the concentration of Staphylex in the blood, and therefore increases the risk of side effects.
- Methotrexate - a cytotoxic drug. Staphylex may increase the concentration of methotrexate in the blood, and therefore increases the risk of methotrexate side effects.
- Epirubicin (Epirube) - a cytotoxic drug. Staphylex can reduce the concentration of epirubicin in the blood, and therefore may reduce the effectiveness of epirubicin. Other antibiotics.
Tell your doctor about all medicines and the herbal remedies you are taking.
Staphylex may cause the following side effects:
- Nausea, stomach upset and diarrhea.
- Bruises that appear without an obvious cause.
- Kidney inflammation.
- Pain in the joints or bones.
- Increase in the number of eosinophils in the blood.
- Liver damage (hepatitis and jaundice).
- Allergic reaction.
If you get any side effects, speak to your doctor.
Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.
If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.