Sulpiride - Use | Dosage | Side Effects

Sulpiride is a drug that is classified in the group of benzamide according to its chemical structure and in the group of antidepressants according to its pharmacological activity. It is used to treat schizophrenia and depression. The studies proved that this medicine is effective to relieve symptoms gastroesophageal reflux disease (GERD).1

Contraindications and precautions

Sulpiride is contraindicated in the following conditions:

  • In patients with adrenal tumors (i.e. pheochromocytoma). There have been reports of sudden death due to the application of this drug in patients who have pheochromocytoma.2 Sulpiride increases the level of norepinephrine in the blood3, which is considered to be the main cause of worsening symptoms in patients with pheochromocytoma.
  • In patients who have breast cancer or increased secretion of prolactin. Sulpiride increases the secretion of prolactin4 and may exacerbate the condition in such patients.
  • In patients suffering from acute porphyria (hereditary liver disorder).

Sulpiride should be very cautiously applied in the following conditions:

  • In patients older than 70 years
  • In patients with epilepsy
  • In patients who have any heart disease
  • In patients who have any kidney disease

Sulpiride, pregnancy and breastfeeding

Sulpiride should not be used during pregnancy, especially during the last trimester. Application during the last trimester can cause following symptoms in newborns:

  • Muscle weakness and muscle cramps
  • Difficulty breathing
  • Feeding problems
  • Drowsiness
  • Anxiety

It is excreted in breast milk and breastfeeding should be avoided while taking Sulpiride.


Sulpiride capsules should be taken before meals with 1 cup of water.

Recommended dosage for Sulpiride capsule is given in the table below:

Indication Dosage
Anxiety-depressive disorders The recommended dose range is 100-400 mg twice a day (before breakfast and before dinner)
Schizophrenia The recommended dose range is 400-800 mg twice a day

It is necessary to adjust the dose in patients who have kidney damage, according to the following table:

Degree of renal impairment (expressed by creatinine clearance) Dosage
Creatinine clearance 30-60 ml / min 70% of the usual dosage
Creatinine clearance 10-30 ml/min 50% of the usual dosage
Creatinine clearance less than 10 ml/min 35% of the usual dosage

Sulpiride should not be used in patients younger than 16 years.


Symptoms of an overdose include:

  • Uncontrolled movements of the limbs
  • Disturbance of consciousness, including the complete loss of consciousness
  • Anxiety
  • Low blood pressure

If you take more Sulpiride than your doctor recommended, you should immediately contact your doctor.


Sulpiride should not be used simultaneously with the following medicines:

Side effects

Sulpiride may cause the following side effects:

  • Increased secretion of prolactin which can cause breast enlargement in both, men and women, the appearance of milk in the breasts in men and women who do not breastfeed, menstrual disorders and impotence
  • Impaired concentration
  • Drowsiness
  • Anxiety
  • Neuroleptic malignant syndrome (fever, muscle cramps, tachycardia, shortness of breath, confusion, and other symptoms). If you notice high temperature while taking this medicine, contact your doctor immediately.
  • Low blood pressure
  • Constipation
  • Dry mouth
  • Formation of blood clots in the vein


  1. NCBI link 1
  2. NCBI link 2
  3. NCBI link 3
  4. NCBI link 4

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.