Sunitinib

Sunitinib - Dosage | Side Effects | Use

Sunitinib belongs to the group of medicines which are the following detailed search proven effective against cancer, renal cancer and pancreatic cancer, but more recently research has been conducted into their application in breast cancer. Common for all cancers that certain cell types multiply uncontrollably. For this growth of cancer cells need oxygen and food, and so they need to create new blood vessels to comply with this requirement. Sending a signal (growth factors, for example VEGF ) in a tumor may itself take care of the formation of new blood vessels. Sunitinib block the effect of a growth factor and thereby prevent the development of cancer. Sunitinib works by blocking various enzymes, tyrosine kinase inhibitors, and therefore it is called an inhibitor of tyrosine kinases. Since the blocking of sunitinib enzyme is called a multi - kinase inhibitor. This figure illustrates how the blocking effect of sunitinib-tyrosine kinase, controls the molecules which are necessary for growth of cancer cells, the expansion and the creation of new blood vessels.

Precautions

During sunitinib treatment should avoid grapefruit, as well as some natural remedies (St. John's Wort) because they may increase or decrease the concentration of sunitinib in the blood and thus may influence the effectiveness of therapy or lead to toxicity. Do not take this medicine if you have:

  • Liver disease
  • Kidney disease
  • High blood pressure or any other heart disease
  • A history of stroke or any other heart disease
  • A history of seizures
  • Thyroid disorders
  • Adrenal disorders
  • Blood clotting disorders

Side effects

Fatigue is often occurring during cancer therapy . Usually this occurs in the later part of sunitinib therapy , and decreases during the interruption of the therapy . Patients who feel fatigue should try to conserve energy to good food and drink plenty of fluids . Nausea and vomiting may occur during sunitinib therapy. If patients feel sick should avoid spicy and oily food, avoid hot foods and use appropriate antiemetics. Changes in the mucosa as well as discomfort in the mouth, taste changes, sore mouth or blisters. Usually the symptoms are reduced during long-term treatment, but in certain cases it is necessary to reduce the dosage. Discomfort in the stomach, diarrhea. Diarrhea may be caused by both, the cancer and sunitinib. Losing weight because they do not feel the desire to eat due to the change of taste during therapy , pain in the mouth or nausea. In certain cases, a change may occur on the skin during treatment . The same is withdrawn 2-3 weeks after completion of therapy , but may in some cases be unpleasant . There may be a change in the pigment of hair and skin. In some individuals during the treatment can occur sunitinib elevated blood pressure which are normally treated in the same manner as essential hypertension. High blood pressure can cause headache and dizziness.

Contraindications

Contraindications to the administration of sunitinib is liver and kidney disease, heart disease, high blood pressure, seizures, bleeding or blood clotting disorders in the work of the thyroid and adrenal glands as well as pregnancy.

Overdose

If you apply more than the prescribed dose is, consult your doctor or pharmacist immediately!

If you forget to take the medicine

If you forget to take medication on time, do not use double dose later. Simply continue to use Sunitinib according to the usual schedule.

Interactions (The usage of other medicines)

  • Antibiotics
  • Antituberculosis medicines (such as isoniasid)
  • Phenobarbital
  • Dexamethasone
  • Carbamazepine
  • Oxcarbazepine
  • Phenytoin
  • Antifungal medications ( such as ketoconazole, miconazole etc)
  • Osteoporosis medicines ( such as ibandronate, etidronate, risedronate, alendronate etc)
  • Imatinib
  • Nicardipine

Please note that this list is not complete!

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.