Torasemide - Use | Dose | Side Effects
Torasemide is a drug that belongs to loop diuretics. It is used for the treatment of edema caused by congestive heart failure as well as for the treatment of edema caused by kidney, liver, or lung disease. Torasemide is also indicated for the treatment of essential hypertension and chronic heart failure.
Contraindications and precautions
Torasemide is contraindicated in the following situations:
- Kidney failure
- Pregnancy and lactation
- Low blood pressure
- Hepatic coma
- Co-administration with nephrotoxic drugs
Also, precautions should be taken in the following conditions:
- In patients with second-degree or third-degree AV block
- In patients with low number of platelets, red blood cells, or leukocytes in the blood!
- In patients with gout (Torasemide can cause an increase in uric acid levels in the blood, which can induce an gout attack)
Torasemide, pregnancy and lactation
There is no data demonstrating impact of this drug on the human embryo or fetus. In animal studies, different results were obtained. Teratogenic properties was not observed in rats while in rabbits it was found that high doses of Torasemide may lead to fetal malformations. Therefore, the application of Torasemid is contraindicated during pregnancy.
There is no data whether Torasemid is excreted into breast milk. Breastfeeding should be avoided while taking this diuretic
The usual dosage is 2.5-5 mg once a day. After oral administration of this drug, maximum diuretic effect occurs after 2-3 hours. Doses greater than 5 mg are not recommended because they don't exert a stronger effect on lowering the blood pressure, but they do increase the risk of side effects.
In the treatment of edema higher doses (40 mg daily) can be applied, based on your doctor's assessment.
It is not necessary to adjust the dose in elderly patients.
Application of Torasemid in children under the age of 18 years has not been studied.
Swallow the pill whole with a little liquid, first thing in the morning.
The following drugs should not be concurrently used with Torasemide:
- Digoxin (a medicine used in the treatment of heart failure). Co-administration may lead to a decrease in blood potassium levels (hypokalemia), which can cause serious heart rhythm disorders (arrhythmia).
- Laxatives - they can disrupt electrolyte balance which may also lead to hypokalemia.
- Aminoglycoside antibiotics (gentamicin, amikacin, and streptomycin). Torasemide increases the risk of nephrotoxicity of these drugs.
- Cephalosporin antibiotics. Torasemide increases nephrotoxicity of these drugs.
- Lithium (a drug used to treat psychiatric disorders). Torasemide increases the risk of cardiotoxicity and neurotoxicity of lithium.
- Drugs for diabetes treatment. Torasemide may reduce the effect of these drugs and lead to hyperglycemia.
- Non-steroidal anti-inflammatory drugs. These drugs reduce the hypotensive effect of Torasemide.
Torasemide may cause the following side effects:
- Disturbance of the electrolyte balance (hypokalemia)
- Loss of appetite
- Urinary retention
- Elevation of the liver enzymes in the blood
- Decrease in the number of red blood cells, platelets and leukocytes in the blood