Velosef - Dosage | Side Effects | Use

Velosef (Cephradine) is an antibiotic of the cephalosporin group (I group) which acts bactericidal. This effect is achieved by inhibiting enzymes involved in the synthesis of the cell wall of bacteria.

It is effective in the treatment of infections caused by the following microorganisms:

  • All types of gram positive microorganism,
  • Beta-hemolytic streptococcus,
  • Streptococcus pneumoniae,
  • Staphylococcus (coagulase-positive, coagulase-negative, penicillinase-producing strains),
  • Escherichia coli,
  • Proteus mirabilis,
  • Klebsiella species,
  • Moraxella (Branhamella) catarrhalis,
  • Bacteroides species (except Bacteroides fragilis),
  • Subtype of sensitive gram-negative microorganism (Haemophilus influenzae, Salmonella, Shigella).

First-generation of cephalosporins, including Velosef, are excellent medicines for the treatment of skin and soft tissue infections caused by S. aureus and the S.pyogenes.

Medicines use (Indications)

Velosef is indicated for the treatment of infections which are caused by agents who are sensitive to the effects of Velosef.

Respiratory tract infections

Upper respiratory tract infection:

  • tonsillitis,
  • pharyngitis,
  • sinusitis,
  • laryngitis.

Ear infection

Otitis media

Infections of skin and soft tissue

  1. Lymphadenitis,
  2. abscess,
  3. cellulitis,
  4. decubital ulcer,
  5. mastitis,
  6. furunculosis,
  7. erysipelas.

Infections of the genitourinary tract

  1. Pyelonephritis,
  2. cystitis.

Dosage and administration

Take Velosef with a full glass of water, with or without food.


Infection Dose
Pharyngitis 250 mg every 6 hours or 500 mg every 12 hours
Otitis media 250 mg every 6 hours or 500 mg every 12 hours
Cystitis Complicated: 500 mg every 6 hours or 1 g every 12 hoursUncomplicated: 500 mg every 12 hours
Pyelonephritis 500 mg to 1 g every 12 hours for 14 days
Upper respiratory infection 250 mg every 6 hours or 500 mg every 12 hours
Skin or soft tissue infection 250 mg every 6 hours or 500 mg every 12 hours

Children (9 months or older)

Infection Dose
Pharyngitis 25-50 mg/kg/day in divided doses every 6 to 12 hours
Otitis media 75-100 mg/kg/day in divided doses every 6 to 12 hours
Bacterial infection 25-50 mg/kg/day in divided doses every 6 to 12 hours
Upper respiratory infection 25-50 mg/kg/day in divided doses every 6 to 12 hours
Skin and structure tissue infection 25-50 mg/kg/day in divided doses every 6 to 12 hours

Maximum dose is 4 g per day!

Use with food and drinks

Velosef can be taken with or without food. It is better to take it with food because that can decrease some of side effects.

Warning and precautions

Do not use this medicine if:

  • You have a hypersensitivity to Velosef or a cephalosporin antibiotics such as:
    • cefaclor (Raniclor),
    • cefadroxil (Duricef),
    • cefazolin (Ancef),
    • cefdinir (Omnicef),
    • cefditoren (Spectracef),
    • cefpodoxime (Vantin),
    • cefprozil (Cefzil),
    • cefuroxime (Ceftin),
    • cephalexin (Keflex),
    • ceftazidime,
    • ceftibuten,
    • cefepime,
    • cefixime etc.
  • Serious hypersensitivity reactions (e.g. anaphylactic reactions) on any beta-lactam antibiotics (penicillins , monobactams or carbapenems) in history.

Before initiation of therapy should be excluded hypersensitivity to cephalosporins or penicillins (for cross- hypersensitivity particularly with regard to beta-lactam antibiotics). The occurrence of severe hypersensitivity reactions requires cessation of therapy and taking emergency medical measures.

If diarrhea occurs it should determine whether it is a consequence of the development of pseudomembranous colitis. Positive diagnosis involves taking the necessary therapeutic measures. As with other antibiotics, Velosef prolonged therapy can result in increased development of others, this medicine insensitive, pathogenic microorganisms.

Velosef should be applied cautiously in patients who have a personal history of gastrointestinal diseases, especially colitis. Experience with the implementation of the medicine in neonates and preterm infants is limited, so the medicine should be used with caution. Cefadroxil can be used with caution in patients with impaired renal function (creatinine clearance).

Use with other medicines (Interactions)

Do not use this medicine during the treatment with Velosef:

  • Warfarin (Coumadine).
  • Furosemide (Lasix),
  • torasemide,
  • ethacrynic acid (Edecrin),
  • Probenecid (Benemid)
  • vancomycin,
  • tobramycin,
  • streptomycin,
  • kanamycin,
  • neomycin,
  • netilmicin,
  • gentamicin,
  • amikacin.

Please may note that this list is not complete.

Laboratory tests

During treatment with Velosef may occur a false positive laboratory analysis (direct Coombs test, glucose in the urine). If you need to make laboratory tests (such as blood and urine tests) note your doctor that you are taking Velosef tablets.

Pregnancy and lactation

Although animal studies and clinical experience have not provided evidence of teratogenicity, safecy to use Velosef during pregnancy has not been established. The medicine is excreted in breast milk, so it should be used with caution in nursing women. Tell your doctor if you are pregnant or plan to become pregnant.

Side effects

  • Diarrhea,
  • nausea,
  • vomiting,
  • urticaria,
  • skin rash,
  • pruritus,
  • jaundice,
  • fever,
  • flu symptoms,
  • seizure,
  • bleeding,
  • tightness,
  • yellow skin,
  • dark urine,
  • confusion,
  • weakness,
  • headache,
  • dizziness,
  • loss of appetite,
  • swelling,
  • weight gain,
  • numbness,
  • muscle weakness,
  • bruising,
  • skin rash,
  • feeling restless or hyperactive,
  • pain in joints,
  • neutropenia,
  • eosinophilia,
  • leukopenia.

Please inform your doctor if any of side effects occur!


If you apply more than the prescribed dose is, consult your doctor or pharmacist! If you apply more medication than you should, contact your doctor or nearest hospital for help. Take medicine box with you, as this will facilitate its identification.

If you forget to take the medicine

If you forget to take medication, do not use double dose later. Simply continue to use the medicine according to the usual schedule. If you missed medication applied, please do so as soon as possible, and then proceed with its application to the usual schedule and suitably.

Information on this website are provided for educational purposes only and are not intended for medical advice, diagnosis or treatment.

If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.