Xatral SR

Xatral SR - Dosage | Use | Side effects

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Xatral SR is a drug containing alfuzosin as an active pharmaceutical ingredient. It belongs to the group of medications known as alpha-1 antagonists. It works by blocking alpha-1 receptors in the smooth muscles of the prostate, which causes relaxation of these muscles, leading to improvement of the symptoms of benign prostatic hyperplasia (BPH). Xatral SR is an uroselective alpha-1 blocker, which means it blocks only the adrenoreceptors in the prostate and has no effect on alpha receptors in the heart. This medicine relieves symptoms of BPH, such as:

  • Frequent urination
  • Weak stream
  • Nocturia
  • Incomplete urination

Contraindications

Xatral SR is contraindicated in patients with moderately severe or severe renal impairment (creatinine clearance less than 50 ml / min) due to the lack of data on the use of this drug in such patients.

Co-administration with potent inhibitors of CYP3A4 enzyme (e.g. erythromycin, clarithromycin, itraconazole, ketoconazole, fluconazole, voriconazole, indinavir, ritonavir, atazanavir, and others) is contraindicated. Concomitant administration with these drugs leads to a significant increase in plasma concentrations of Xatral SR which may lead to adverse effects.

Since largest part of Xatral SR is metabolized by the liver, it should not be used in patients who have moderate or severe liver damage. Clinically significant increase in plasma concentration may occur in such patients, which increases the risk of side effects.

It is contraindicated in patients under 18 years of age.

Warnings and precautions

Like other alpha blockers, and Xatral SR can cause postural hypotension and syncope (sudden loss of consciousness). Postural hypotension occurs because alpha-1 blockers block vascular alpha-1 receptors, which leads to the dilatation of blood vessels and consequently to a reduction in blood pressure. Syncope is more likely to occur if you get up quickly from a sitting or lying position. For this reason, this medicine must be used with caution in patients who are on antihypertensive therapy.

Since the symptoms of benign prostatic hyperplasia are similar to those of prostate carcinoma, and considering the fact that these two diseases often coexist, it is very important to exclude cancer as a possible diagnosis prior to initiating therapy with this drug. It is recommended to measure the level of prostate-specific antigen (PSA) in the blood in order to detect the possible presence of carcinogenic changes.

This medicine must be very carefully used in cardiac patients, due to possible worsening of the symptoms.

Dosage

The recommended dose is one tablet (10 mg) once daily after a meal. Make sure you take the tablet at the same time each day.

Interactions

Concomitant use with the following drugs is contraindicated, as it can lead to an increase in plasma levels of Xatral SR:

  • HIV protease inhibitors - medicines used to treat AIDS and hepatitis C, such as: amprenavir, atazanavir, and boceprevir.
  • Antibiotics, such as: clarithromycin, erythromycin, telithromycin, and azithromycin.
  • Cobicistat.
  • Nefazodone.

Concomitant use with the following drugs is contraindicated, as it can cause arrhythmias:

  • Fluoroquinolones - medicines used for the treatment of infections, such as: moxifloxacin, norfloxacin and ciprofloxacin.
  • Anagrelide - a medicine used for the treatment of thrombocytosis
  • Antiretroviral drugs (e.g. efavirenz)
  • Bedaquiline - a medicine for the treatment of tuberculosis
  • Cisapride - gastrointestinal prokinetic substance
  • Bepridil and diltiazem - calcium blockers used to treat angina
  • Antiarrhythmic drugs, such as: sotalol, ibutilide, quinidine, dronedarone and amiodarone.
  • Ceritinib - a medicine used to treat lung cancer
  • Clozapine, olanzapine, droperidol and haloperidol - antipsychotics
  • Citalopram - anxiolytic

Side effects

The following side effects have been associated with Xatral SR:

  • Dizziness (affects 5% of patients)
  • Infections of the nose, tonsils and throat (affects 3% of patients)
  • Headache (affects 3% of patients)
  • Fatigue (affects 2.7% of patients)
  • Postural hypotension (affects 0.4% of patients)
  • Syncope (affects 0.2% of patients)
  • Bronchitis (affects 1-2% of patients)
  • Nausea and vomiting (affects 1-2% of patients)
  • Impotence
  • Tachycardia
  • Pain in the chest
  • Priapism
  • Flushing
  • Diarrhea or constipation
  • Allergic reactions
  • Visual disturbances
  • Hepatotoxicity
  • Dry mouth
  • Palpitations
  • Urinary incontinence

References

  1. accessdata link
  2. PIL

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