Xergic - Dosage | Overdose | Precautions

This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.

Xergic is a medicine that contains an active substance called fexofenadine and belongs to the second generation H1-antihistamines intended for systemic use. It has not demonstrated a sedative effect. The effects of Xergic begin one hour after use, while the maximum anti-allergic effect occurs about 6 hours after taking the pill. Effects of the drug last for 24 hours.

Xergic works by blocking histamine H1-receptors which prevents histamine's harmful effects (histamine is a substance that is released during an allergic reaction).

For this reason, Xergic is used to alleviate the symptoms of allergic rhinitis (also known as hay fever) in patients above the age of 12. Symptoms of allergic rhinitis include frequent sneezing, itching and redness of the nose, runny nose, itchy feeling or burning sensation in the throat, and increased tearing.

Xergic can also be used to alleviate the symptoms of chronic idiopathic urticaria.

Precautions and Interactions

In patients with impaired renal function, an increase in the concentration of the active substance - fexofenadine in the blood by more than 80% was observed (depending on the degree of renal damage). Therefore, the initial dose in patients with impaired renal function should be decreased (60 mg once a day).

Xergic should not be used concomitantly with an antibiotic called erythromycin or with an antifungal medicine called ketoconazole, as these medicines significantly increase the concentration of Xergic in the blood, thereby increasing the risk of side effects.

If you use antacids containing magnesium or aluminum, you should take them separately - at least two hours after you take your Xergic tablet.

It is not recommended for use in children under the age of 12.

If there is no improvement in the symptoms after 7 days, you should contact your doctor.

Xergic does not exhibit sedative effects, and therefore it should not affect your ability to operate machinery.

Xergic, Pregnancy and Breastfeeding

Studies in rats have shown that the use of fexofenadine at doses that are 3 times greater than the maximum recommended dose in humans can lead to weight loss and decreased survival rates of the fetus, which is why FDA classify this drug in pregnancy category C. Xergic can be used during pregnancy only if your gynecologist estimates that the potential benefit to the mother is greater than the potential risk to the child.

Xergic has not shown any teratogenic effect in animal studies.

The use of Xergic should be avoided during breastfeeding, although there are no data on whether this medicine is excreted in human milk.


The recommended dose for adults and children above the age of 12 is 120 mg once a day, before meals.


Cases of an overdose were very rarely reported. Possible symptoms of overdose include dizziness, drowsiness and dry mouth. In the case of an overdose, the therapy should be symptomatic. Hemodialysis cannot help to remove fexofenadine from the blood.

Side effects

Side effects of Xergic include:

  • Nausea and vomiting.
  • Viral infections.
  • Headache.
  • Upper respiratory tract infections.
  • Painful menstrual periods.
  • Drowsiness.
  • Fatigue.
  • Back pain.
  • Coughing.
  • Fever.
  • Middle ear infection.
  • Dizziness.
  • Tightness in the chest.
  • Difficulty breathing.
  • Pain in your arms or legs.
  • Pain in the joints.
  • Pain in the ear.
  • Diarrhea.
  • Loss of voice.
  • Insomnia.
  • Nervousness.
  • Rapid heartbeat.
  • Allergic reactions.

Tell your doctor if you are experiencing any side effects.


  1. FDA

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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.

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