Yomax

Yomax - Precautions | Dosage | Side effects

Yomax is a medicine that contains amoxicillin as an active substance. It belongs to a group of penicillin antibacterial and is used to treat the following infections:

  • Ear infections
  • Throat infections
  • Genital tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Lower respiratory tract infections
  • Eradication of Helicobacter pylori

This drug does not work against bacteria that produce beta-lactamase (an enzyme that breaks down all beta-lactam antibiotics).

It is effective against a large number of bacteria, including:

  • Haemophillus influenzae
  • Escherichia coli
  • Streptococcus spp.
  • Staphylococcus spp.
  • Enterococcus faecalis
  • Proteus mirabilis

The FDA recommends the use of this drug only when it is clear that infection is caused by bacteria because in this way you will reduce the development of bacteria that are resistant to antibiotics.

Yomax is not effective against colds and flu unless they are caused by bacteria.

Precautions

Do not use this medicine if you are allergic to the active substance - amoxicillin or other penicillin-class antibacterial (e.g. ampicillin, phenoxymethylpenicillin, and others). There is data on the occurrence of cross-sensitivity between cephalosporin-class and penicillin-class antibacterial, and patients who are allergic to cephalosporin antibiotics (e.g. cefalexin, ceftazidime, cefuroxime, cefixime, ceftriaxone, cefachlor, cefepime, ceftibuten, and others) should not use this medicine. Serious and life-threatening allergic reactions are most commonly reported in patients who are on therapy with parenteral penicillin antibiotics but cases of severe allergic reactions in patients who are on the treatment with oral amoxicillin have also been reported.

It should not be used in patients suffering from infectious mononucleosis, as it may cause worsening of symptoms.

Diarrhea caused by a bacterium called Clostridium difficile has been reported in patients who are taking this drug. The severity of this adverse effect varies and can have fatal outcome. Yomax kills bacteria in the intestine, causing excessive reproduction of Clostridum difficile. This bacterium then produces toxins that express their effects on the whole body. If you notice diarrhea while using this medicine, contact your doctor immediately.

Yomax, Pregnancy and Breastfeeding

This drug belongs to Group B - group of medicines that have not demonstrated adverse effects on the fetus during animal studies, but there are insufficient well-controlled and adequate studies on pregnant women that can confirm the safety of its use during human pregnancy. However, since infections can have serious health consequences for the fetus, doctors often prescribe this medication during pregnancy.

Avoid breastfeeding while using Yomax.

Dosage

Recommended dosage (adults and children weighing more than 40 kg):

The recommended dose for mild infections of the ear, nose, throat, genital tract and urinary tract is 500 mg twice a day or 250 mg three times a day.

The recommended dose for severe infections of the ear, nose, throat, genital tract and urinary tract is 875 mg twice a day or 500 mg three times a day.

The recommended dose for infections of the lower respiratory tract is 875 mg twice a day or 500 mg three times a day.

Recommended dosage (children weighing less than 40 kg):

The recommended dose for mild infections of the ear, nose, throat, genital tract and urinary tract is 12.5 mg / kg twice a day or 6.3 mg / kg three times a day.

The recommended dose for severe infections of the ear, nose, throat, genital tract and urinary tract is 22.5 mg / kg twice a day or 13.3 mg / kg three times a day.

The recommended dose for infections of the lower respiratory tract is 22.5 mg / kg twice a day or 13.3 mg / kg three times a day.

For example:

If your child has a mild ear infection and weigh 30 kg, then the dose should be calculated as follows:

30 x 12.5 = 375 mg, which means your child should take 375 mg twice a day (every 12 hours).

Yomax should be taken one hour before or two hours after food.

Interactions

Yomax should not be taken concurrently with the following medicines:

  • Oral contraceptives (e.g. Yasmin). Yomax reduces the efficacy of these drugs, and it is recommended to use alternative contraceptive methods for at least one month after you stopped taking Yomax.
  • Probenecid - a medicine used to treat gout. Probenecid reduces the tubular renal secretion of Yomax leading to an increase in plasma levels of Yomax which increases the risk of side effects.
  • Allopurinol - a medicine used to treat gout. Simultaneous administration increases the incidence of skin rash, but the exact mechanism responsible for this adverse effect remains unknown.
  • Oral anticoagulants. There have been reports of an increase in INR in patients taking these drugs concomitantly. Your doctor will reduce the dose of oral anticoagulant while you're taking Yomax.

Side effects

According to the FDA, the most commonly reported adverse reactions (occurring in more than 1% of patients) are:

  • Nausea and vomiting
  • Diarrhea
  • Skin rash

In addition, Yomax can cause the following side effects:

  • Hemolytic anemia
  • Thrombocytopenia
  • Allergic reactions (including anaphylactic shock)
  • Thrombocytopenic purpura
  • Leukopenia
  • Eosinophilia
  • Change in tooth color (yellow or gray colored teeth) that usually disappears after brushing the teeth
  • Crystalluria
  • Insomnia
  • Confusion
  • Dizziness
  • Changes in behavior
  • Urinary turbidity
  • Urinary difficulty
  • Hyperactivity
  • Feeling exhausted
  • Convulsions

References

  1. NCBI link
  2. accessdata link